Antiamoebic Drugs

Antiamoebic Drugs

Write In Brief About Antiamoebic Drugs And Their Significance In Dental Pharmacology.
Answer:

Antiamoebic drugs are those which are used to treat amoebiasis caused by the protozoan known as entamoeba histolytica.

Classification Of Antiamoebic Drugs

1. Tissue amoebicides

• For both intestinal and extraintestinal amoebiasis:
  • Nitroimidazoles, i.e. metronidazole, tinidazole, Secnidazole
  • Alkaloids: Emetine, dehydroemetine.
• For extraintestinal amoebiasis, i.e. chloroquine.

Antiamoebic Drugs: Types, Mechanism of Action, and Uses

2. Luminal amoebicides

• Amide: Diloxamide furoate, nitazoxanide
• 8-hydroxyquinolines, i.e. quiniodochlor, diiodohydroxyquin
• Antibiotics: Tetracyclines.

Antiamoebic Drugs In Brief

Significance Of Antiamoebic Drugs In Dental Pharmacology

• Metronidazole is used in the treatment of alveolar abscesses, pericoronitis, periodontitis, etc.
• Metronidazole is used in acute ulcerative gingivitis. It is given as 200 to 400 mg for a week.
• Tinidazole is used in oriental anaerobic infections. It is given as 600 mg BD for 5 days.
• Tetracyclines are mainly used in chronic periodontitis. They are also used in the treatment of acute necrotizing ulcerative gingivitis.