Oral Lichen Planus: Pathogenesis, Clinical Features, and Histopathology

Oral Lichen Planus: Pathogenesis, Clinical Features, and Histopathology

Question 1. Describe pathogenesis, clinical manifestations, and histopathological features of oral lichen planus.

“Common challenges in diagnosing oral lichen planus effectively: FAQs provided”

Answer. Pathogenesis

• Oral lichen planus is a T cell-mediated autoimmune disease in which cytotoxic CD8+ + T cells trigger the apoptosis of oral epithelial cells.
  The CD8+8 + lesional T cells may recognize the antigen associated with major histocompatibility complex (MHC) class I on keratinocytes.
  After antigen recognition and activationCD8+D8 + cytotoxic T cells may trigger keratinocyte apoptosis.
  ActivatCD8+CD8 + T Cells may release cytokines that attract additional lymphocytes.
• As per the recent studies in pschyoneuro-immunology, psychosomatic stress results in the autoimmunity reactions and this leads to lichen planus.

“Understanding oral lichen planus through FAQs: Q&A explained”

Question 2. What are vesiculobullous lesions? Describe in detail pemphigus.

Answer. Vesicles are the superficial blisters that are 5 mm or less in diameter and are usually filled with clear fluid

A bulla is a large blister that is greater than 5 mm in diameter.

The lesions, which consist of vesicles or bullae, are known as vesiculobullous lesions.

“Importance of studying oral lichen planus for better diagnostic outcomes: Questions explained”

Question 3. Describe the etiopathogenesis of lichen planus.

types of oral lichen planus

Answer. The etiopathogenesis of lichen planus:

• Oral lichen planus is a T cell-mediated autoimmune disease in which cytotoxic CD8+ + T cells trigger the apoptosis of oral epithelial cells. The CD8+8+ lesional T cells may recognize the antigen associated with major histocompatibility complex (MHC) class I on keratinocytes.
  After antigen recognition and activation, CD8+ + cytotoxic T cells may trigger keratinocyte apoptosis.
  ActivatedCD8+8 + T Cells may release cytokines that attract additional lymphocytes.
• As per the recent studies in psychoneuroimmunology, psychosomatic stress results in autoimmune reactions, and this leads to lichen planus.