Cherubism

Cherubism

Question. Write short note on cherubism.
Or
Describe in brief cherubism
Or
Write short essay on cherubism.

“Understanding the role of cherubism in jawbone disorders: Q&A explained”

Answer. Cherubism is an autosomal dominant firo-osseous lesion of the jaw which involves more than one quadrant that stabilizes after growth period leading to facial deformity and malocclusion.

Clinical Features Of Cherubism

• Children of age 1 to 3 years are more commonly affected.
• Males are more commonly affected than females.
• Affected children are normal at birth but as soon the child’s growth take place self­limited bone growth begins to slow down till patient reaches 5 years of age and stop at the age of 12–15 years.
• There is deforming mandibular and maxillary overgrowth with respiratory obstruction and impairment of vision and hearing.
• Enlargement of cervical lymph nodes contributes to the patient’s full-faced appearance.
• A rim of sclera is may be beneath the iris, giving a classic eye-to-heaven appearance.

“Importance of studying cherubism for better diagnostic outcomes: Questions explained”

Oral Manifestations Of Cherubism

• Agenesis of 2nd and 3rd molars of mandible.
• Displacement of the teeth
• Premature exfoliation of primary teeth
• Delayed eruption of permanent teeth
• Transposition and rotation of teeth
• In severe cases tooth resorption occurs.

“Common challenges in diagnosing cherubism effectively: FAQs provided”

Histopathology Of Cherubism

• Lesion presents a highly cellular and vascular connective tissue stroma, which is often arranged in a “whorled pattrn”.
• Numerous proliferating firoblasts and variable numbers of multinucleated giant cells are also found within the stroma.
• Giant cells are relatively smaller in size and they often aggregate around the thin­walled blood capillaries.
• A hallmark of the disease is the presence of an “eosinophilic perivascular cuffing” of collagen fibers, which often surrounds the blood capillaries.
• Within the connective tissue extravasated blood and deposits of hemosiderin pigments are sometimes seen.
• Lymph nodes exhibit reactive hyperplasia, fibrosis and chronic inflammatory cell infiltration.

“Steps to explain the causes of cherubism: Genetic mutations vs environmental factors: Q&A guide”

“Role of SH3BP2 gene mutations in causing cherubism: Questions answered”

Treatment Of Cherubism

No treatment is required as cherubism is a self­limiting disease.