How Does the WHO Define Acute Leukemia? Everything You Need to Know

Classification Of Acute Leukemia

Write a short note on the classification of acute leukemia.
Answer:

Hemophilia A in boys

Acute leukemia Classification

Revised FAB ( French – American – British ) Classification for Acute Myeloid Leukemia

“Importance of the WHO classification in diagnosing acute leukemia”

Revised FAB (French – American – British) Classification for acute Lymphocytic leukemia

“Impact of the WHO on acute lymphoblastic leukemia (ALL) diagnosis”

World Health Organization (WHO) Classification of Acute Leukemias

Blast count for diagnosis of acute leukemia ≥ 20% in peripheral blood or bone marrow (in FAB classification the cut-off is 30%; it has been demonstrated that the survival pattern of patients with 20-30% blasts is similar to those with a count of >30%).

“Complications of delaying acute leukemia diagnosis per WHO”

Hemophilia A causes

1. WHO classification of AML

• AML with recurrent genetic abnormalities
  • AML with t(8; 2l) (q22; q22); AMLl/ETO
  • AML with abnormal bone marrow eosinophils inv(l6) (p l3; q22) or t (16; 16) (p l3; q 22); (CBFβ/MYH 1l)
  • Acute promyelocytic leukemia AML with t(l5; l7)(q 22; q l2) (PML/RARα) and variants
  • AML with 11q23(MLL) abnormalities
• AML with multilineage dysplasia
  • Following a myelodysplastic syndrome
  • Without antecedent myelodysplastic syndrome
• AML and myelodysplastic syndromes therapy-related
  • Alkylating agent related
  • Topoisomerase Type 2 inhibitor-related
  • Other types

Hemophilia A inheritance pattern

“Treatment options for WHO-defined acute leukemia”

• AML not otherwise characterized/specified
• AML minimally differentiated
• AML without maturation
• AML with maturation
• Acute myelomonocytic leukemia
• Acute monoblastic and monocytic leukemia
• Acute erythroid leukemia
• Acute megakaryoblastic leukemia
• Acute basophilic leukemia
• Acute pan melodies with myelofibrosis
• Myeloid sarcoma
• Myeloid proliferations related to Down’s syndrome
• Blastic plasmacytoid dendritic cell neoplasms

“Pathophysiology of acute leukemia explained by the WHO”

2. Classification of ALL