Antimalarial Drugs Question And Answers

Antimalarial Drugs Question And Answers

Question 1. Describe The Drug Therapy For Acute Malarial Fever Due To P. Vivex.
Answer:

“Role of heme detoxification inhibition by chloroquine”

Following is the drug therapy for acute malarial fever due to P. vivex:

• Chloroquine 600 mg base followed by 300 mg base after 6 hours for the first day.
• 300 mg base second day
• 300 mg base third day.

“Understanding the role of antimalarial drugs in treating malaria”

Question 2. Classify Antimalarial Drugs According To Their Intervention In Lifecycle Of Malaria Parasite.
Answer:

Classification Of Antimalarial Drugs According To Their Intervention In the Life Cycle Of Malaria

1. Tissue schizontocidal agents: These drugs act on primary (pre-erythrocytic) and latent tissue forms (hypnozoites) in the liver, For Example. primaquine is effctive in both forms; atovaquone and proguanil act on primary form.

2. Blood schizontocidal agents: These drugs act on the erythrocytic stage of plasmodium and terminate the clinical attack.

• Rapidly acting and high efficacy agents: Chloroquine, artemisinin derivatives, quinine, mefloquine, atovaquone, amodiaquine, lumefantrine.
• Slow-acting and low efficacy agents: Proguanil, pyrimethamine + sulphadoxine, clindamycin. These drugs should be indicated with rapidly acting agents.

“Techniques for managing high-risk groups with malaria”

3. Gamitocidal agents: These drugs kill gametocytes of plasmodia in blood, For Example. artemisinin and primaquine:

These are active against all species.

Chloroquine and quinine: These are active against vivex form. These drugs also reduce transmission to mosquitoes.