Physiology Of Gastric Acid Secretion
Describe the mechanism of secretion of HCI by the gastric mucosa.
Answer:
- HCI secretion is active process occurring in the canaliculi of parietal cells in gastric glands
- Carbon dioxide is formed from metabolic activity combines with water and forms carbonic acid in presence of carbonic anhydrase
- Carbonic acid quickly splits into hydrogen ion and bicarbonate ion
- H+ ion is pumped into the lumen of canaliculi in exchange of ATP
- Clion enters the canaliculi actively
- It is derived from NaCl in blood
- NaCl -> Na+ + Cl
- Bicarbonate ion combines with sodium ion to form sodium bicarbonate
- Na+ HCO3 -> NaHCO3
- Thus H+ ion and Clion combines in the lumen of canaliculi to form HCl
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