Pancreatic Juice

Pancreatic Juice

Describe the composition, functions and regulation of secretion of pancreatic juice.
Answer:

Pancreatic Juice Composition:

• Pancreatic juice contains
  1. Water-99.5%
  2. Solids -0.5%
     1. Organic substances – enzymes
        • Proteolytic enzymes – trypsinogen, carboxypepditase, elastase
        • Nucleases – deoxyribonucleases
        • Amylolytic – pancreatic amylase
        • Lipolytic pancreatic lipase, phospholipase
     2. Inorganic substances
        • Cations
          • Sodium, potassium, calcium, magnesium, zinc
        • Anions
          • Bicarbonate, chloride, phosphate, sulphate

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Pancreatic Juice Functions:

• Digestive function
  • Enzymes present in the pancreatic juice helps in digestion of proteins, lipids and carbohydrates
• Neutralizing action
  • As soon as acidic chyme enters intestine from stomach, large quantity of pancreatic juice with its alkaline bicarbonate content is release into intestine
  • This alkaline bicarbonate neutralizes the acidic chyme
  • Thus, intestine is protected from the destructive action of acidic chyme

Pancreatic Juice Regulation:

Pancreatic Juice Stages:

1. Cephalic phase

Regulated by two reflexes:

• Unconditioned reflex- occurs when food is placed in mouth
• Conditioned reflex – occurs due to sight, smell, hearing or thought of food

Nervous Pathway:

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2. Gastric phase

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3. Intestinal phase

• Entry of chyme into intestine constitute intestinal phase
• By its entry, hormones are release which may stimulate/ inhibit pancreatic secretion.

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