Wound Healing – Primary Intention – Secondary Intention

Wound Healing – Primary Intention – Secondary Intention

• In primary healing of wound edges are approximated by surgical sutures.
• In the initial phase, there will be formation of blood clot, which helps to hold the parts of the wound together.
• The tissue becomes edematous and an inflmmatory process starts, with the infitration of polymor-phonuclear neutrophils (PMN) and lymphocytes into the area.
• The tissue debris collected in the wound are cleared either by the process of phagocytosis or by their lysis with the help of proteolytic enzymes, liberated by the inflammatory cells.

“Factors influencing success with wound healing knowledge: Q&A”

• Once the tissue debris are cleared, granulation tissue forms that replaces the blood clot in the wound, and it usually consists of young blood capillaries, proliferating firoblasts, PMN, and other leukocytes.
• The epithelium at the edge of the wound starts to proliferate and gradually, it covers the entire wound surface.
• Finally, the healing process is complete with progressive increase in the amount of dense collagen bundles and decrease in the number of inflammatory cells in the area.

“Importance of studying wound healing intentions for healthcare professionals: Questions explained”

• When the opposing margins of the wound cannot be approximated together by suturing, the wound fils in from the base with the formation of a larger amount of granulation tissue, such type of healing of the open wound is known as healing by “secondary intention” or “secondary healing”.
• The secondary healing occurs essentially by the same process as seen in the primary healing, the only diffrence is that a more severe inflammatory reaction and an exuberant firoblastic and endothelial cell proliferation occur in the later.

“Common challenges in managing wound healing by primary and secondary intention effectively: FAQs provided”

• In secondary healing, once the blood clot is removed,the granulation tissue fils up the entire area and the epithelium begins to grow over it, until the wound surface is completely epithelized.
• Later on, the inflmmatory exudates disappear slowly and the firoblasts produce large amounts of collagen.
• Most of the healing processes occurring due to secondary intention, result in scar formation at the healing site.